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  • Writer's pictureLauren Fang

Med of the Week: Hydrocodone & Acetaminophen


Hydrocodone and Acetaminophen feature with white pills

Hydrocodone & Acetaminophen, also commonly known as Norco or Vicodin, is frequently prescribed by dentists. It’s critical that dentists understand the risks associated with Hydrocodone & Acetaminophen. Read on to learn:


Generic Name: Hydrocodone Bitartrate and Acetaminophen

Brand Name(s): Anexsia, Hycet, Norco, Liquicet, Lorcet, Lorcet Plus, Lortab, Maxidone, Vicodin, Vicodin ES, Verdrocet, Xodol, Zamicet, Zolvit, Zydone

Pronunciation: hye droe KOE done and a SEET a MIN oh fen


About this drug:

  • Hydrocodone & Acetaminophen is used to relieve moderate to severe pain.

  • It contains an opioid narcotic and may become habit forming.


Dentistry-related tidbits:

  • Hydrocodone & Acetaminophen may cause xerostomia if used long-term.

  • This medication can decrease blood pressure. Always check the patient’s blood pressure and pulse before a procedure.

  • Monitor blood pressure when administering Bupivacaine, Lidocaine, Mepivacaine, and Ropivacaine to a patient taking Hydrocodone & Acetaminophen, as the combination may increase the risk of methemoglobinemia and severe hypotension.

  • Respiratory depression (serious breathing problem) occurs more frequently in the elderly. This medication may also cause severe lightheadedness, fainting, and problems with balance, especially in the elderly.

  • For post-procedural pain, first attempt pain control by prescribing 400-600 mg of Ibuprofen and 500-1000 mg of Acetaminophen at the same time. Take every 6 hours as needed for pain. Never exceed 4000 mg per day to avoid liver complications. Consider using Bupivacaine (Marcaine) local anesthetic to minimize post-op pain.

  • Metoprolol has numerous drug interactions with commonly prescribed NSAIDs, antibiotics, antifungals, benzodiazepines, muscle relaxants, and more. Make sure to check for potential interactions before prescribing using a tool like Rx Check.

  • Consider prescribing Naloxone (Narcan) if there is a risk of opioid overdose or accidental ingestion.


Fun facts:

  • This medication has multiple FDA Warnings. Examples include risks for medication errors, addiction and abuse, respiratory depression, and concomitant use with benzodiazepines/other CNS depressants. Ensure you are aware of these warnings before prescribing any medications.

  • Do not prescribe this medication if the patient is pregnant to avoid life-threatening symptoms in the baby.

  • Instruct patients to not take additional Acetaminophen while taking this medication to avoid liver problems.

  • Vicodin was reformulated in 2012 to comply with FDA regulations limiting the amount of Acetaminophen in each dose.

  • Three million US citizens and 16 million individuals worldwide have had or currently suffer from opioid use disorder (OUD).


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