Carvedilol, the first beta blocker approved for heart failure, contains cautions regarding its interactions with antibiotics, pain relievers, and local anesthetics. Continue reading to understand how this medication will impact your dental treatment and prescribing:
Generic Name: Carvedilol
Brand Name(s): Coreg, Coreg CR
Pronunciation: KAR ve dil ole
About this drug:
Carvedilol is a nonselective β-adrenergic blocker used to treat high blood pressure, heart failure and other conditions not listed.
It may also reduce the risk of death after a heart attack.
Dentistry-related tidbits:
Carvedilol may cause thrombocytopenia.
Monitor blood pressure and heart rate when administering common local anesthetics like Articaine, Bupivacaine, Lidocaine, Mepivacaine, and Ropivacaine to a patient taking Carvedilol. This combination may increase the risk of hypotension and bradycardia.
Epinephrine can decrease the antihypertensive efficacy of Carvedilol when combined.
Carvedilol may mask some of the symptoms of hypoglycemia, especially tachycardia.
Steroids, NSAIDs, Aspirin and Aspirin containing products in combination with Carvedilol may increase hypertension.
Some narcotics in combination with Carvedilol may increase the risk of severe hypotension, including orthostasis and syncope.
Exercise caution when prescribing macrolide antibiotics and azole antifungals to avoid an increased risk of hypotension, AV block, and bradycardia. Make sure to check for potential interactions before prescribing using a tool like Rx Check.
Fun facts:
Carvedilol blocks beta-1, beta-2 and alpha-1 adrenergic receptors, resulting in decreased heart rate, myocardial contractility, and peripheral vasoconstriction.
Carvedilol is contraindicated if the patient has conditions such as severe bradycardia (unless the patient has a permanent pacemaker) or severe hepatic failure.
This medication is one of the only three FDA approved beta blockers for heart failure.
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